New World of Darkness has an after the end setting presented in Shards with rules for things like high radiation spots, fallout storms, and other environmental hazards plus supernatural threats like slaver vampires, ghost swarms, and rolling freeform spells.
Easy character generation and tons of equipment, especially if you have access to Armory, Armory: Reloaded, or Hunter: The Vigil, plus extremely lethal, easy to use combat rules.