What I'd run (and will run, as soon as I find other players and have time), is D&D and 4th Ed specifically. None of the gamers I play with now like D&D at all. In fact, most make a point of bashing D&D on a regular basis and they especially hate 4e (though I find it ironic that most of them love Saga Edition Star Wars while hating D&D4e). So, while I do like all these people and they are my friends, I can't run D&D with them. Almost any other game I'd think about running (In Nomine, Cthulhutech, Call of Cthulhu, etc), they'd be great for. But I want some fragging D&D, damn it.