At the moment, I'm running several games over Skype.
DC Adventures (M&M3e)- Orange Lanterns have begun invading various planets. The Justice League is dispatched to help various worlds and protect their own. The players are various new recruits to the JLA and get caught up in a battle over their heads when several large portable Orange Lantern batteries land on Earth, summoning up alien constructs to defend them. The PCs were attempting to secure Styker Island when one crashes there and Lex Luthor emerges wearing a Orange Lantern Ring. So far they were trounced royally, but plan on trying to make another run at it. It's a fairly standard, and not too imaginative but the group likes it.
Werewolf the Forsaken - The same group that does the DC Adventures game. We rotate what we play on a week by week basis as half the group really likes WoD, and the other half would rather play something else. The group plays a pack in Detroit. They're trying to prevent an all out war between the Werewolves and Vampires of the city. This isn't going so well because of some of their own actions, so at the moment, they're just trying to gather up allies and protect their own territory, since it looks like they're about to be right in the middle of a throw down.
A Song Of Ice and Fire Roleplaying - I've set it about a year before the events of Game of Thrones. They've created a Noble House in the Westerlands and received a land grant from Tywin Lannister. Their original plan was to redevelop the land and clear it of Bandits. This was going well, but then a player dropped out, and a new player joined. They agreed to let him play the formers character, who was the heir of the House. Some bad decisions later, and they've pissed of another House in the Westerlands who have antagonized a conflict between the Player's House and their northern neighbors from the Riverlands, all while funding Bandits and Mercenaries to invade other parts of their lands while their troops are occupied on the northern border.
I'm also running a one on one game for my wife using All Flesh Must Be Eaten, specifically Fistful o' Zombies.
I have several planned games I'm working on
I'm trying out Interface Zero 2.0, which is the Cyberpunk setting for Savage Worlds with my wife as soon as we finish her campaign with Fistful o' Zombies. Not entirely sure what the plot will be yet.
I have a Mortals/God-Machine Chronicles game planned out. It will be set in the Ozarks, though the place will be a bit more hillbilly than it actually is. I may even set it a bit back in time, but not any earlier than the 80's. The group live in a town a few miles away from cult's compound. I'm going to ask one of the players to add a few specifics to their background. Mainly that their parents are recruited into the cult, and they took the PC's mentally disturbed sister with them. The parents end up dead, and the PC becomes the legal guardian. The cult wont hand over the sister though, and the local authorities claim jurisdictinal issues and manpower prevent them from just raiding the compound. The cult wont give up the girl without a fight though, because she's a Stigmatic and can see the God-Machines workings and his servants. They fear it, and worship some Demon or whatever, that has led them up into the hills to be free of it's influence.
Once the Werewolf game ends, the players asked me to run a All Flesh Must Be Eaten game for them. I'm doing one on a cruise ship. We've named the campaign "Love Boat of the Dead". The ship has a full on outbreak, and the boat has already been ordered back to US waters and into quarantine due to 3/4 of the passengers and crew coming down with some virus. The infected have died and come back to life now. The players are trapped at the rear of the boat, with the ship still moving along, but no ones heard from the captain or command crew in almost a day.
Only War (from the Warhammer 40k line) will happen eventually, with the plot being the arrival of the full Tyranid Hive Fleet. It's the end of the Imperium of Man, but maybe the characters can find a way to survive.