I think I've cooked up a good initial scenario for my "Futurama" campaign intro idea, meant to be a way to introduce the setting to players who haven't read the books.
The PCs are volunteer subjects of a very pre-Fall cryogenic project. Their backstories aren't really all that important; maybe each one has a basic character archetype like "techie" or "soldier". They go down for the nap, but unbeknownst to them the project is intended to be much more long-term than they were told.
They are awoken in a mostly ruined secret facility on post-Fall Earth, after a Firewall agent accidentally wakes them up hunting for some intel Macguffin. They meet the agent just long enough to see him get brutally killed by a TITAN robot. But he's running a backup fork in a ghostrider module, so he's still there, he just needs them to be his hands and feet to help him complete the mission, promising to farcast them out as a reward. So they do the operation, asking the agent whatever questions about their new world they want.
Upon their success, they get farcasted to a Firewall body bank on Titan, but since their very existence would prove that the operation took place, they're given the choice of either deletion or joining Firewall. They get muses and skillsofts to get them up to speed with current tech needs, and the campaign progresses more normally from there.