I ran a short lived Venture Bros. themed game. I had the players make PL 7 characters who where aspiring to either become heroes or join the Guild of Calamitous Intent. Each "team" had to share an apartment and the apartments, while in seperate buildings, are only about three feet apart because they are on the same floors in their respective building. The place was a developement style building complex so the structures where built in a half circle and very close together.
The game basically consisted of the would-be villains trying to think of things to do to build their street cred while the heroes listened to them through the window and followed the villains whenever they left, thinking they could thwart the villains and gain some standing.
It wasn't a serious game, the players bearly knew how to work the system, two out of five people never even really used their powers, and we only played once but there was some fun. Alot of time was devoted to heroes and villains shouting at each other through their windows and then me (using my wide range of colorful accents) cutting in as other people in the developement complex shouting at them for shouting. There was a quick fight right at the end becasue the heroes followed the villain group supermarket that somebody else was robbing, which got everyone involved in a fight.
Best part was the villain players started calling the heroes "The Campers", and since they where yelling it during the supermarket fight I decided the name stuck with the public.
So my suggestion is: do not mix heroes and villains into the same over all playing group unless they are experienced enough to handle it. However, do start your players off sharing an apartment. It is hiliarious, especially if any of the players have every shared living space with any of the other players.