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« on: August 06, 2012, 10:26:27 PM »
I'm not familiar with Wild Talents or Godlike, so I can't answer that.
Mutants and Masterminds is pretty simple if you're already familiar with the d20 system; I know you said one of your players knew D&D 4.0, and Char-Gen aside, D&D is much harder to play than M&M2e.
The one issue with M&M2e is that it's character creation involves a good deal of math and planning, and for new players, that could very well prove overwhelming. It does come with a lot of pre-made character archetypes already written up in the book (and you can easily find some online), which your players could of course repurpose for their own needs.
Combat and damage are pretty simple; if you want to hit someone with a targeted attack, you roll your attack bonus for that attack, and compare the number to their defense; if you roll higher, you hit, if you roll lower, you miss.
Area attacks always 'hit' - but they allow reflex saves for half (or no) damage. Perception ranged attacks always hit no matter what, so be real judicious about allowing these.