Not really sure about San Diego, but I would guess that you can find some gamers and games in San Diego.
I live north of SD, in Oceanside and there is a local meetup group that meets for D&D 4th Ed. Strangely enough, they do so on Tuesdays so I haven't been able to attend any of the meet-up groups.
There is a local comic shop called Pair-A-Dice that will host space for games on most days of the week. I've gone a few times, but I've never been brave enough to approach any of the guys there because they seem rather "clannish" and I've taken Ross' "no gaming is better than bad gaming" advice to heart...
Anyway, I wish you luck out here. San Diego is really a very nice place to live, although it can get a bit expensive. The weather is mostly beautiful and there are some really nice women to look at!