Coincidence! The Civil War CoC scenario that I ran for Caleb and Ross at Fear the Con in June (and again for Aaron, Jason, and David among others at Springfield G.A.M.E. a few weeks ago) features an Indian mound rather prominently. And it should be hitting the Actual Play site pretty soon!
I have to say, I really enjoyed playing in that game at G.A.M.E.!
In regards to the topic however, I would love to see RPPR play through one or two sessions of Rogue Trader, as it was the game that really got me serious with roleplaying. I know Ross expressed his neutral-ness with the setting though, and you really need someone who is really invested in the setting in order to truly bring the game to the fantastic potential that it holds.