I got an idea for a Twin Cities Red Markets setting. I live there and I think one major feature makes it a novel place to set a game. The Mississippi River. In the setting detail Caleb describes that the river is the moat to the zombie barricade. So i imagined Two Cities on each side of the river. The St. Paul Safe Zone which is part of the Recession. And Minneapolis Enclaves which are part of the Loss. This has made the Minneapolis Enclaves actually a central Red Market trading hub. Other Loss enclaves send traders there to buy and trade in needed goods that were traded across the few bridges still in place.
This makes Minneapolis (what's left of it) a Taker Mecca. It also has agents from Ubiq and DHQS embedded in the populace. It is a place of intrigue, commerce and violence.
That's a great idea, somewhat similar to my ideas for St. Louis, Missouri (which would be a huge hub for trade and infiltration from the Loss to the Recession, since the Missouri River is the safest and fastest way to get from the depths of the Loss to the border).
I think a border-centered enclave is likely to be a major sub-setting for a certain campaign style. Working right on the border is going to have a totally different feel than a game set way out in some place like Colorado or on the West Coast.
Thematically, I'd say a border campaign would emphasize the economic horrors of wealth disparity, black markets as a response to over-regulation, and corruption. A more western/deep recession game would likely focus more on resource scarcity, environmental damage, and isolation. And a West Coast game would focus on smoking weed and surfing.