We were playing a DG game a few years back where we raided a cultist church and somehow got transported to an alien craft. My FBI DG-friendly was mowing cultists and alien creatures down with a shotgun with dragon fire rounds, and losing massive sanity as he did so, with five out of my first seven or so rolls being in the ought-one to ought-nine range. There were body parts everywhere. (At close range, a shotgun in CoC does 6d6 or 8d6, I forget which, on a character that has usually 12-14 HPs.)
By the time we got transported to the ship my character was temporarily crazed and I was playing him like he had more of a hair-trigger than he did. At this point, Jason's character gets taken over by one of the aliens and shoots my character in the back at point blank range with a 9mm. The 9mm barely does damage because of my body armor and I swing the shotgun, with again dragon fire rounds, on him and say, "You son of a bitch."
And roll a double-ought. The shotgun explodes as it jams killing my character instantly and mortally wounding Jason's. The damage done to Jason was enough to break his trance, but the other character abandoned him as they fled back out the portal.